research

Our lab explores the intricate relationship between aging and cellular ecosystems, focusing on how senescence influences tissue dynamics and organ function in vivo. We investigate how senescent cells shape their microenvironment through secreted factors, altering biomechanical signals and disrupting the mechanical milieu that maintains tissue homeostasis. By leveraging unbiased approaches, we aim to uncover the fundamental mechanisms driving the propagation of senescence across cellular networks and organs. Our work seeks to illuminate how these changes contribute to aging and disease, providing new insights into the systemic impact of the senescence-associated secretory phenotype (SASP) on biological systems.